Bioinformatics of Autoimmune Diseases (Chapman & Hall/CRC Computational Biology Series)

Autoimmune diseases arise when the immune system misidentifies the body’s own tissues as threats, a catastrophic failure of self-recognition that leads to chronic inflammation, tissue damage, and long-term disability.Bioinformatics of Autoimmune Diseases is a timely and comprehensive guide that explores not only the immunological basis of these disorders but also the cutting-edge bioinformatics approaches used to analyze the genomic, transcriptomic, and epigenomic data driving modern discovery. Structured to bridge foundational immunology with advanced computational analysis, this book offers readers a progression from the molecular mechanisms of immune function and dysfunction to the bioinformatics pipelines used to investigate them.Early chapters provide a thorough grounding in immune cell biology, immune checkpoints, and disease pathogenesis.Subsequent chapters guide readers through practical analyses of autoimmune disease data, covering RNA-Seq, variant analysis, microbiome profili