Epigenetics in Neurodegenerative Disorders: Mechanisms, Biomarkers, and Therapeutic Perspectives (Epigenetics and Human Health, 17)

Epigenetic mechanisms are increasingly recognised as key contributors to neurodegenerative disease processes, shaping the molecular pathways involved in ageing, neuroinflammation and neuronal dysfunction.This volume provides an integrated overview of how DNA methylation, histone modifications, chromatin remodelling, non-coding RNAs and epitranscriptomic regulation influence the onset and progression of neurodegenerative disorders. Covering a broad spectrum of conditions-including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal dementia, prion and prion-like diseases, amyotrophic lateral sclerosis and multiple sclerosis-the book examines how epigenetic alterations interact with genetic, metabolic and environmental factors to drive disease pathology.Contributors detail advances in biomarker development, such as DNA methylation profiles, differentially methylated and hydroxymethylated regions, extracellular vesicles and neurofilament light chain, along with