Stem Cell-free Therapy: Engineering Exosomes and Secretomes for Next-Generation Therapeutics

This book provides a comprehensive review of the advancements in cell-free therapeutic applications, focusing on the biological and biomedical potential of mesenchymal stem cell (MSC)-derived secretome and extracellular vesicles (EVs) in disease treatment and tissue repair.It examines the mechanistic functions of MSC-derived biomolecules and the regulatory landscape shaping their development.The discussion then progresses to innovative strategies for enhancing the MSC secretome through priming techniques, optimizing its biological activity for therapeutic applications.The book examines the application of exosome-based and EV-driven therapies across a broad range of biomedical fields, including neuroscience, cardiology, ophthalmology, gastroenterology, and oncology.Further, it highlights the role of MSC-derived secretome in treating neurocognitive disorders, autoimmune diseases, diabetes complications, and inflammatory conditions, with a special focus on innovations in drug delivery, ti